Trifluoroacetic acid → HCID 178511651, compound

HRID 2271721Notes

Reaction equation

[CH:1]1([C:4]([C:6]2[CH:7]=[N:8][C:9]3[C:14]([C:15]=2[NH:16][C@H:17]2[CH2:22][CH2:21][C@H:20]([NH:23]C(=O)OC(C)(C)C)[CH2:19][CH2:18]2)=[CH:13][C:12]([C:31]2[CH:36]=[CH:35][N:34]=[CH:33][CH:32]=2)=[CH:11][CH:10]=3)=[O:5])[CH2:3][CH2:2]1.C(O)(C(F)(F)F)=O>>[NH2:23][C@H:20]1[CH2:19][CH2:18][C@H:17]([NH:16][C:15]2[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:31]4[CH:36]=[CH:35][N:34]=[CH:33][CH:32]=4)[CH:13]=3)[N:8]=[CH:7][C:6]=2[C:4]([CH:1]2[CH2:2][CH2:3]2)=[O:5])[CH2:22][CH2:21]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 178454018HCID 178454018, compound

Product 1

HCID 178511651HCID 178511651, compoundYield 39%

Procedure

Following general procedure A-2, tert-butyl trans-4-[3-(cyclopropanecarbonyl)-6-(pyridin-4-yl)quinolin-4-ylamino]cyclohexylcarbamate (50 mg, 0.100 mmol) was reacted with TFA (2 mL) to afford the desired product (14.9 mg, 39%) as a yellow solid: NMR (500 MHz, CD3OD) δ 9.26 (s, 1H), 8.70 (dd, J=4.6, 1.6 Hz, 2H), 8.65 (s, 1H), 8.30 (dd, J=8.7, 1.7 Hz, 1H), 8.05 (d, J=8.7 Hz, 1H), 7.87 (dd, J=4.6, 1.7 Hz, 2H), 4.31 (br s, 1H), 3.28-3.22 (m, 1H), 2.91-2.82 (m, 1H), 2.41 (d, J=13.2 Hz, 2H), 2.20 (d, J=11.3 Hz, 2H), 1.82-1.69 (m, 2H), 1.67-1.55 (m, 2H), 1.28-1.23 (m, 2H), 1.20-1.16 (m, 2H); ESI MS m/z 387 [C24H26N4O+H]+; HPLC 95.0% (AUC), tR=8.34 min.

Sources & evidence

ORD record: ord-64908803c796448ea62f1569f9d972c2
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09120749B2

Reaction notes

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