反应详情

Following general procedure A-2, tert-butyl cis-4-[3-(cyclopropanecarbonyl)-6-(3,5-difluoro-4-hydroxyphenyl)quinolin-4-ylamino]cyclohexylcarbamate (51 mg, 0.095 mmol) was reacted with TFA (2 mL) to afford the desired product (25 mg, 52%) as a light yellow solid: 1H NMR (300 MHz, CD3OD) δ 9.27 (s, 1H), 8.37 (d, J=1.7 Hz, 1H), 8.06 (dd, J=8.8, 1.9 Hz, 1H), 7.94 (d, J=8.7 Hz, 1H), 7.33 (dd, J=8.1, 1.6 Hz, 2H), 4.73 (s, 1H), 2.97-2.86 (m, 1H), 2.16 (d, J=9.1 Hz, 2H), 2.09-1.97 (m, 5H), 1.91-1.76 (m, 2H), 1.27-1.20 (m, 2H), 1.20-1.10 (m, 2H); ESI MS m/z 438 [C25H25F2N3O2+H]+; HPLC>99% (AUC), tR=5.12 min.