反应详情

Following general procedure A-2, tert-butyl trans-4-[6-(3,5-dichloro-4-hydroxyphenyl)-3-isobutyrylquinolin-4-ylamino]cyclohexylcarbamate (60 mg, 0.100 mmol) was reacted with TFA (2 mL) to afford the desired product (20.3 mg, 43%) as a yellow solid: 1H NMR (500 MHz, CD3OD) δ 8.98 (s, 1H), 8.33 (s, 1H), 8.02 (d, J=8.8 Hz, 1H), 7.93 (d, J=8.7 Hz, 1H), 7.67 (s, 2H), 4.18 (s, 1H), 3.80-3.70 (m, 1H), 2.96 (s, 1H), 2.40 (d, J=11.4 Hz, 2H), 2.20 (d, J=12.2 Hz, 2H), 1.73 (q, J=11.1 Hz, 2H), 1.65-1.53 (m, 2H), 1.24 (d, J=6.8 Hz, 6H); ESI MS m/z 472 [C25H27Cl2N3O2+H]+; HPLC 98.7% (AUC), tR=10.95 min.