反应详情

Following general procedure A-2, tert-butyl trans-4-[3-acetyl-6-(3,5-difluoro-4-hydroxyphenyl)quinolin-4-ylamino]cyclohexylcarbamate (30 mg, 0.059 mmol) was reacted with TFA (2 mL) to afford the desired product (14.2 mg, 59%) as a yellow solid: 1H NMR (500 MHz, CD3OD) δ 8.98 (s, 1H), 8.35 (d, J=1.9 Hz, 1H), 8.07-8.00 (m, 1H), 7.93 (d, J=8.7 Hz, 1H), 7.33 (dd, J=8.0, 1.6 Hz, 2H), 4.29 (s, 1H), 3.23 (s, 1H), 2.71 (s, 3H), 2.41 (d, J=12.2 Hz, 2H), 2.19 (d, J=12.1 Hz, 2H), 1.76-1.67 (m, 2H), 1.63-1.54 (m, 2H); ESI MS m/z 412 [C23H23F2N3O2+H]+; HPLC 98.7% (AUC), tR=8.13 min.