反应详情

Following general procedure A, (S)-tert-butyl 1-(5-(6-(3,5-dichloro-4-hydroxyphenyl)-3-propionylquinolin-4-ylamino)pyridin-2-yl)piperidin-3-ylcarbamate (50 g, 0.078 mmol) was treated with a solution of 3N HCl to afford desired product (36.2 mg, 72%) as a yellow-orange solid: 1H NMR (500 MHz, MeOD) δ 9.29 (s, 1H), 8.25 (m, 2H), 8.05 (m, 2H), 7.85 (d, J=8.8 Hz, 1H), 7.31 (m, 3H), 4.52 (s, 1H), 4.06 (d, J=12.6 Hz, 1H), 3.81 (m, 3H); 2.16 (q, J=7.0 Hz, 2H), 2.22 (s, 1H), 1.98 (s, 1H), 1.24 (t, J=7.0 Hz, 3H); APCI MS m/z 536 [C28H27Cl2N5O2+H]+; HPLC 98.7% (AUC), tR=10.30 min.