Trifluoroacetic acid → HCID 178511271, compound

HRID 2271941Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][C:14]([C:20]([CH:22]2[CH2:24][CH2:23]2)=[O:21])=[C:13]3[NH:25][C@H:26]2[CH2:31][CH2:30][C@H:29]([CH2:32][NH:33]C(=O)OC(C)(C)C)[CH2:28][CH2:27]2)[CH:5]=[C:6]([F:9])[C:7]=1[OH:8].C(O)(C(F)(F)F)=O>>[NH2:33][CH2:32][C@H:29]1[CH2:30][CH2:31][C@H:26]([NH:25][C:13]2[C:12]3[C:17](=[CH:18][CH:19]=[C:10]([C:4]4[CH:5]=[C:6]([F:9])[C:7]([OH:8])=[C:2]([Cl:1])[CH:3]=4)[CH:11]=3)[N:16]=[CH:15][C:14]=2[C:20]([CH:22]2[CH2:23][CH2:24]2)=[O:21])[CH2:27][CH2:28]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 178453638HCID 178453638, compound

Product 1

HCID 178511271HCID 178511271, compoundYield 40%

Procedure

Following general procedure A-2, tert-butyl {trans-4-[6-(3-chloro-5-fluoro-4-hydroxyphenyl)-3-(cyclopropanecarbonyl)quinolin-4-ylamino]cyclohexyl}methylcarbamate (0.123 mmol) was reacted with TFA (2 mL) to afford the desired product (23 mg, 40% over two steps) as a yellow solid: 1H NMR (300 MHz, CD3OD+TFA-d) δ 9.37 (s, 1H), 8.45 (s, 1H), 8.26 (d, J=8.7 Hz, 1H), 7.98 (d, J=8.7 Hz, 1H), 7.63-7.47 (m, 2H), 4.51 (s, 1H), 2.92-2.83 (m, 3H), 2.46-2.40 (m, 2H), 2.11-1.98 (m, 2H), 1.83-1.63 (m, 3H), 1.32-1.14 (m, 6H); ESI MS m/z 468 [C26H27ClFN3O2+H]+; HPLC 98.6% (AUC), tR=11.33 min.

Sources & evidence

ORD record: ord-6d64fd89d67046eb961ce24c049ca478
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09120749B2

Reaction notes

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