Hydrochloric Acid → Hydrochloric Acid

HRID 2271998Notes

Reaction equation

HRID 2271998 reaction equation
[ClH:1].C(OC([N:9]1[C@@H:18]2[C@@H:13]([C:14]3[C:22]([O:23][C:24]4[N:25]=[N:26][C:27]([CH3:30])=[CH:28][CH:29]=4)=[CH:21][CH:20]=[CH:19][C:15]=3[CH2:16][CH2:17]2)[CH2:12][CH2:11][CH2:10]1)=O)(C)(C)C>ClCCl>[CH3:30][C:27]1[N:26]=[N:25][C:24]([O:23][C:22]2[C:14]3[C@@H:13]4[C@H:18]([CH2:17][CH2:16][C:15]=3[CH:19]=[CH:20][CH:21]=2)[NH:9][CH2:10][CH2:11][CH2:12]4)=[CH:29][CH:28]=1.[ClH:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86654080HCID 86654080, compound

Product 2

HCID 313Hydrochloric AcidHCID 86654081HCID 86654081, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Hydrochloric acid (4 mol/L in 1,4-dioxane, 0.7 mL) is added to a solution of cis-10-(6-methyl-pyridazin-3-yloxy)-2,3,4a,5,6,10b-hexahydro-1H-benzo[f]quinoline-4-carboxylic acid tert-butyl ester (0.13 g) in dichloromethane (5 mL) at room temperature. The solution is stirred at room temperature for 2 h and then concentrated to give the crude title compound as its hydrochloric acid salt that is used without further purification. Yield: 0.12 g (crude); LC (method 1): tR=1.90 min; Mass spectrum (ESI+): m/z=296 [M+H]+.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-e94f60e7362643f7833fdfd55e611a35
Source dataset
uspto-grants-2015_09
Patent number
US09120769B2

Reaction notes

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