Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | HCID 17974870 | HCID 17974870 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 17974872 | HCID 17974872 | 45.6% |
Reaction Steps
Methanesulfonyl chloride (0.14 ml) was added to an ice-cooled solution of 1-(2-hydroxyethyl)-1-phenyl-3-(4-trifluoromethyl-3-pyridylcarbonyl)thiourea (0.60 g) and triethylamine (0.42 ml) in dichloromethane, and stirred for 3 hours at 20° C. The mixture was washed (water), dried (magnesium sulfate), evaporated and the residue recrystallized (ethanol) to give 3-phenyl-2-(4-trifluoromethyl-3-pyridylcarbonyl)iminothiazolidine (0.26 g, Compound D-60).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07560456B2 |
|---|
| Source dataset | uspto-grants-2009_07 |
|---|
| ORD ID | ord-f3e58546143648d49a406b0cf421ac69 |
|---|
| Source note | uspto-grants-2009_07 |
|---|
