Triethylamine → HCID 17974872, compound

HRID 227228Notes

Reaction equation

HRID 227228 reaction equation
CS(Cl)(=O)=O.O[CH2:7][CH2:8][N:9]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:10]([NH:12][C:13]([C:15]1[CH:16]=[N:17][CH:18]=[CH:19][C:20]=1[C:21]([F:24])([F:23])[F:22])=[O:14])=[S:11].C(N(CC)CC)C>ClCCl>[C:25]1([N:9]2[CH2:8][CH2:7][S:11][C:10]2=[N:12][C:13]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][C:20]=2[C:21]([F:24])([F:23])[F:22])=[O:14])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 17974870HCID 17974870, compound

Product 1

HCID 17974872HCID 17974872, compoundYield 45.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
20 °C

Procedure

Methanesulfonyl chloride (0.14 ml) was added to an ice-cooled solution of 1-(2-hydroxyethyl)-1-phenyl-3-(4-trifluoromethyl-3-pyridylcarbonyl)thiourea (0.60 g) and triethylamine (0.42 ml) in dichloromethane, and stirred for 3 hours at 20° C. The mixture was washed (water), dried (magnesium sulfate), evaporated and the residue recrystallized (ethanol) to give 3-phenyl-2-(4-trifluoromethyl-3-pyridylcarbonyl)iminothiazolidine (0.26 g, Compound D-60).

Workup

  1. washThe mixture was washed (water)
  2. dry with materialdried (magnesium sulfate)
  3. customevaporated
  4. customthe residue recrystallized (ethanol)

Sources & evidence

ORD record
ord-f3e58546143648d49a406b0cf421ac69
Source dataset
uspto-grants-2009_07
Patent number
US07560456B2

Reaction notes

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