HCID 122643076, compound → HCID 131732335, compound

HRID 2272390Notes

Reaction equation

HRID 2272390 reaction equation
[Br:1][C:2]1[C:11]([Cl:12])=[CH:10][C:9]([N:13]([C:18]2[C:37]([CH:38]3[CH2:40][CH2:39]3)=[CH:36][C:21]3[C:22]([C:32](=[O:35])[NH:33][CH3:34])=[C:23]([C:25]4[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=4)[O:24][C:20]=3[CH:19]=2)[S:14]([CH3:17])(=[O:16])=[O:15])=[CH:8][C:3]=1[C:4](OC)=[O:5].[Li+].[BH4-].C1COCC1>C1COCC1.CO.[Cl-].[Na+].O>[Br:1][C:2]1[C:3]([CH2:4][OH:5])=[CH:8][C:9]([N:13]([C:18]2[C:37]([CH:38]3[CH2:40][CH2:39]3)=[CH:36][C:21]3[C:22]([C:32]([NH:33][CH3:34])=[O:35])=[C:23]([C:25]4[CH:26]=[CH:27][C:28]([F:31])=[CH:29][CH:30]=4)[O:24][C:20]=3[CH:19]=2)[S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:11]=1[Cl:12]

Participants

6

Reactant 2

HCID 122643076HCID 122643076, compoundHCID 131718764lithium borohydride THF

Product 1

HCID 131732335HCID 131732335, compoundYield 104.3%

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolventHCID 57417360Sodium chloride; waterSolvent

Procedure

A solution of 54.3 g (84.0 mmol) of crude methyl 2-bromo-3-chloro-5-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)benzoate in 351 mL of anhydrous THF and 39 mL of anhydrous MeOH was cooled in an ice water/brine bath to −5° C. (internal temperature). To the stirred solution was added 125 mL (251 mmol) of 2M LiBH4/THF via addition funnel at a rate so as to maintain the temperature below 5° C. The addition required 35 minutes. The brine bath was then replaced by an ice water bath and stirring of the solution continued. After another 1.5 hours LCMS indicated complete reaction. The solution was quenched by addition of 200 mL of saturated aqueous sodium bicarbonate followed by 400 mL of water and 600 mL of EtOAc. The mixture was stirred vigorously for 30 minutes and then transferred to a separatory funnel. After the phases separated, solid remained in the aqueous phase so an additional 200 mL of water was added and the mixture shaken, and the phases again separated. The aqueous solution was extracted with EtOAc (2×200 mL). The combined EtOAc solutions were washed with 5% aqueous NaCl (1×), saturated brine (1×), dried over sodium sulfate and concentrated to dryness at reduced pressure to afford 54.5 g of 6-(N-(4-bromo-3-chloro-5-(hydroxymethyl)phenyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide as an orange-brown foam. The crude material was carried forward to the next step without purification. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.45-8.54 (m, 1H) 8.12 (s, 1H) 7.98 (dd, J=8.93, 5.41 Hz, 2H) 7.59 (d, J=2.73 Hz, 1H) 7.54 (d, J=2.63 Hz, 1H) 7.41 (t, J=8.88 Hz, 2H) 7.22 (s, 1H) 5.64 (t, J=5.56 Hz, 1H) 4.48 (d, J=5.56 Hz, 2H) 3.45 (s, 3H) 2.84 (d, J=4.59 Hz, 3H) 2.06-2.17 (m, 1H) 0.75-1.06 (m, 3H) 0.47 (br. s., 1H). LCMS(ESI): 623 (M+H+).

Workup

  1. additionvia addition funnel at a rate so as
  2. temperatureto maintain the temperature below 5° C
  3. additionThe addition required 35 minutes
  4. customreaction
  5. customThe solution was quenched by addition of 200 mL of saturated aqueous sodium bicarbonate
  6. stirringThe mixture was stirred vigorously for 30 minutes
  7. customtransferred to a separatory funnel
  8. customAfter the phases separated
  9. additionwas added
  10. stirringthe mixture shaken
  11. customthe phases again separated
  12. extractionThe aqueous solution was extracted with EtOAc (2×200 mL)
  13. washThe combined EtOAc solutions were washed with 5% aqueous NaCl (1×), saturated brine (1×)
  14. dry with materialdried over sodium sulfate
  15. concentrationconcentrated to dryness at reduced pressure

Sources & evidence

ORD record
ord-5b1c312474014edcbeee47a6b6af3d5b
Source dataset
uspto-grants-2015_09
Patent number
US09119868B2

Reaction notes

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