Hydrochloric Acid → HCID 118037691, compound

HRID 2272471Notes

Reaction equation

HRID 2272471 reaction equation
[CH:1]1([C:4]2[CH:9]=[C:8]([CH2:10][N:11]3[CH2:16][CH2:15][CH:14]([N:17]4[CH:22]=[CH:21][C:20]([C:23]([O:25]C)=[O:24])=[CH:19][C:18]4=[O:27])[CH2:13][CH2:12]3)[C:7]([O:28][CH:29]([CH3:31])[CH3:30])=[CH:6][C:5]=2[C:32]2[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=2)[CH2:3][CH2:2]1.[OH-].[Na+].Cl>C(O)C>[CH:1]1([C:4]2[CH:9]=[C:8]([CH2:10][N:11]3[CH2:16][CH2:15][CH:14]([N:17]4[CH:22]=[CH:21][C:20]([C:23]([OH:25])=[O:24])=[CH:19][C:18]4=[O:27])[CH2:13][CH2:12]3)[C:7]([O:28][CH:29]([CH3:31])[CH3:30])=[CH:6][C:5]=2[C:32]2[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=2)[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 118037898HCID 118037898, compound

Product 1

HCID 118037691HCID 118037691, compoundYield 70.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixed solution of methyl 1-(1-((2-cyclopropyl-4′-fluoro-5-isopropoxybiphenyl-4-yl)methyl)piperidin-4-yl)-2-oxo-1,2-dihydropyridine-4-carboxylate (103 mg), a 1 M aqueous sodium hydroxide solution (1 mL), and ethanol (2 mL) was stirred at 70 C for 1 hour. The obtained reaction solution was neutralized with 1 M hydrochloric acid and, in this state, stirred at room temperature for 3 hours. The resulting solid was collected by filtration and recrystallized (ethyl acetate) to obtain the title compound (70.3 mg).

Workup

  1. customThe obtained reaction solution
  2. filtrationThe resulting solid was collected by filtration
  3. customrecrystallized (ethyl acetate)

Sources & evidence

ORD record
ord-eb1da2406afd4c8a968a6cc46deabc22
Source dataset
uspto-grants-2015_09
Patent number
US09120777B2

Reaction notes

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