反应详情

A mixture of methyl 5-(benzyloxy)-2-cyclopropyl-2′,4′-difluorobiphenyl-4-carboxylate (20.3 g), 10% palladium carbon (containing 55% water, 10.0 g), and THF (100 mL) was stirred at room temperature for 1 hour in a hydrogen atmosphere of balloon pressure. The catalyst was filtered off, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain the title compound (15.0 g).

1. filtrationThe catalyst was filtered off
2. distillationthe solvent was distilled off under reduced pressure
3. customThe obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate)