Hydrochloric Acid → 2,4'-Difluoro-3-hydroxy-[1,1'-biphenyl]-4-carbaldehyde

Participants

Reaction Steps

6 M hydrochloric acid (49.1 mL) was added to an ethanol (160 mL) solution of 2,4′-difluoro-3-(methoxymethoxy)biphenyl-4-carbaldehyde (16.4 g). The reaction mixture was stirred at 50 C for 30 minutes and further at room temperature for 2 hours. The resulting solid was collected by filtration and then washed with ethanol-water and water in this order to obtain the title compound (12.7 g).

Provenance & Evidence