Hydrochloric Acid → 2,4'-Difluoro-3-hydroxy-[1,1'-biphenyl]-4-carbaldehyde

HRID 2272507Notes

Reaction equation

HRID 2272507 reaction equation
Cl.[F:2][C:3]1[C:8]([O:9]COC)=[C:7]([CH:13]=[O:14])[CH:6]=[CH:5][C:4]=1[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=1>C(O)C>[F:2][C:3]1[C:8]([OH:9])=[C:7]([CH:13]=[O:14])[CH:6]=[CH:5][C:4]=1[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118037657HCID 118037657, compound

Product 1

HCID 904239512,4'-Difluoro-3-hydroxy-[1,1'-biphenyl]-4-carbaldehydeYield 92%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

6 M hydrochloric acid (49.1 mL) was added to an ethanol (160 mL) solution of 2,4′-difluoro-3-(methoxymethoxy)biphenyl-4-carbaldehyde (16.4 g). The reaction mixture was stirred at 50 C for 30 minutes and further at room temperature for 2 hours. The resulting solid was collected by filtration and then washed with ethanol-water and water in this order to obtain the title compound (12.7 g).

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with ethanol-water and water in this order

Sources & evidence

ORD record
ord-472cf7188b904757ad620c1c58bca0cc
Source dataset
uspto-grants-2015_09
Patent number
US09120777B2

Reaction notes

Loading…