Hydrochloric Acid → Methyl 3-methyl-2-oxo-1-(piperidin-4-yl)-1,2-dihydropyridine-4-carboxylate hydrochoride

Participants

Reaction Steps

To 2M hydrogen chloride (2-propanol solution 2.85 L) was added methyl 1-(1-(tert-butoxycarbonyl)piperidin-4-yl)-3-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate (200 g) at room temperature. The mixture was stirred at room temperature for 18 hours. Diisopropyl ether (11.5 L) was added to the reaction mixture and the precipitate was collected by filtration, washed with diisopropyl ether (2.86 L) to give the title compound (163.2 g).

Provenance & Evidence