反应详情

To 2M hydrogen chloride (2-propanol solution 2.85 L) was added methyl 1-(1-(tert-butoxycarbonyl)piperidin-4-yl)-3-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate (200 g) at room temperature. The mixture was stirred at room temperature for 18 hours. Diisopropyl ether (11.5 L) was added to the reaction mixture and the precipitate was collected by filtration, washed with diisopropyl ether (2.86 L) to give the title compound (163.2 g).

1. filtrationthe precipitate was collected by filtration
2. washwashed with diisopropyl ether (2.86 L)