Hydrochloric Acid → HCID 118037888, compound

Participants

Reaction Steps

A 2 M aqueous sodium hydroxide solution (1 mL) was added at room temperature to a methanol (4 mL) solution of methyl 1-(1-((2-cyclopropyl-4′-fluoro-5-isopropoxybiphenyl-4-yl)methyl)piperidin-4-yl)-3-ethyl-2-oxo-1,2-dihydropyridine-4-carboxylate (390 mg), and the mixture was stirred at 60 C for 1 hour in a nitrogen atmosphere and then neutralized with 1 M hydrochloric acid. The reaction mixture was stirred at room temperature for 30 minutes, and then, the deposited crystal was collected by filtration and recrystallized (diisopropyl ether/ethanol) to obtain the title compound (240 mg).

Provenance & Evidence