Hydrochloric Acid → HCID 118037888, compound

HRID 2272539Notes

Reaction equation

HRID 2272539 reaction equation
[OH-].[Na+].[CH:3]1([C:6]2[CH:11]=[C:10]([CH2:12][N:13]3[CH2:18][CH2:17][CH:16]([N:19]4[CH:24]=[CH:23][C:22]([C:25]([O:27]C)=[O:26])=[C:21]([CH2:29][CH3:30])[C:20]4=[O:31])[CH2:15][CH2:14]3)[C:9]([O:32][CH:33]([CH3:35])[CH3:34])=[CH:8][C:7]=2[C:36]2[CH:41]=[CH:40][C:39]([F:42])=[CH:38][CH:37]=2)[CH2:5][CH2:4]1.Cl>CO>[CH:3]1([C:6]2[CH:11]=[C:10]([CH2:12][N:13]3[CH2:18][CH2:17][CH:16]([N:19]4[CH:24]=[CH:23][C:22]([C:25]([OH:27])=[O:26])=[C:21]([CH2:29][CH3:30])[C:20]4=[O:31])[CH2:15][CH2:14]3)[C:9]([O:32][CH:33]([CH3:35])[CH3:34])=[CH:8][C:7]=2[C:36]2[CH:41]=[CH:40][C:39]([F:42])=[CH:38][CH:37]=2)[CH2:4][CH2:5]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 118038006HCID 118038006, compound

Product 1

HCID 118037888HCID 118037888, compoundYield 63.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 2 M aqueous sodium hydroxide solution (1 mL) was added at room temperature to a methanol (4 mL) solution of methyl 1-(1-((2-cyclopropyl-4′-fluoro-5-isopropoxybiphenyl-4-yl)methyl)piperidin-4-yl)-3-ethyl-2-oxo-1,2-dihydropyridine-4-carboxylate (390 mg), and the mixture was stirred at 60 C for 1 hour in a nitrogen atmosphere and then neutralized with 1 M hydrochloric acid. The reaction mixture was stirred at room temperature for 30 minutes, and then, the deposited crystal was collected by filtration and recrystallized (diisopropyl ether/ethanol) to obtain the title compound (240 mg).

Workup

  1. stirringThe reaction mixture was stirred at room temperature for 30 minutes
  2. filtrationthe deposited crystal was collected by filtration
  3. customrecrystallized (diisopropyl ether/ethanol)

Sources & evidence

ORD record
ord-57322d7892074f5e8bd698b2f3a80e3b
Source dataset
uspto-grants-2015_09
Patent number
US09120777B2

Reaction notes

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