Hydrogen Peroxide → HCID 57413677, compound

HRID 2272544Notes

Reaction equation

HRID 2272544 reaction equation
[C:1]([NH:5][C:6]1[CH:13]=[C:12]([N:14]2[C:22]3[C:17](=[C:18]([N:23]4[CH:27]=[C:26]([C:28]5[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=5)[N:25]=[CH:24]4)[CH:19]=[CH:20][CH:21]=3)[C:16]([CH:34]([CH3:36])[CH3:35])=[N:15]2)[CH:11]=[CH:10][C:7]=1[C:8]#[N:9])([CH3:4])([CH3:3])[CH3:2].[OH-:37].[Na+].OO.O>CS(C)=O>[C:1]([NH:5][C:6]1[CH:13]=[C:12]([N:14]2[C:22]3[C:17](=[C:18]([N:23]4[CH:27]=[C:26]([C:28]5[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=5)[N:25]=[CH:24]4)[CH:19]=[CH:20][CH:21]=3)[C:16]([CH:34]([CH3:36])[CH3:35])=[N:15]2)[CH:11]=[CH:10][C:7]=1[C:8]([NH2:9])=[O:37])([CH3:4])([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 784Hydrogen PeroxideHCID 962WaterHCID 14798Sodium HydroxideHCID 86700750HCID 86700750, compound

Product 1

HCID 57413677HCID 57413677, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

To a solution of compound (1b) in DMSO (4.41 mL) were added 4N aqueous sodium hydroxide solution (160 μL) and 30% aqueous hydrogen peroxide solution (60 μL), and the mixture was stirred at room temperature for 10 minutes. After completion of the reaction, water was poured into the reaction solution, and the precipitated solid was collected by filtration to obtain compound (1) (150 mg, yield 96%) as a white solid.

Workup

  1. additionwas poured into the reaction solution
  2. filtrationthe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-77fcdb003b1f4b2bad45c8f9e3972b6f
Source dataset
uspto-grants-2015_09
Patent number
US09120780B2

Reaction notes

Loading…