Hydrogen chloride-ethyl acetate → HCID 86729739, compound

HRID 2272580Notes

Reaction equation

HRID 2272580 reaction equation
[CH2:1]([N:3]1[C:15]2[CH:14]=[CH:13][C:12]([NH:16][C:17](=[O:29])[CH2:18][CH2:19][CH2:20][NH:21]C(=O)OC(C)(C)C)=[CH:11][C:10]=2[C:9]2[C:4]1=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH3:2].[ClH:30].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:30].[NH2:21][CH2:20][CH2:19][CH2:18][C:17]([NH:16][C:12]1[CH:13]=[CH:14][C:15]2[N:3]([CH2:1][CH3:2])[C:4]3[C:9]([C:10]=2[CH:11]=1)=[CH:8][CH:7]=[CH:6][CH:5]=3)=[O:29]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86729738HCID 86729738, compound

Product 1

HCID 86729739HCID 86729739, compoundYield 74.2%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of the compound obtained in Step 1 (1.0 g, 2.53 mmol) and 4M hydrogen chloride/ethyl acetate (4 mL, 16.00 mmol) in ethyl acetate (10 mL) was stirred at room temperature for 14 hr. The precipitate was collected by filtration, and washed with ethyl acetate to give 4-amino-N-(9-ethyl-9H-carbazol-3-yl)butanamide hydrochloride (0.622 g, 1.875 mmol, 74.2%) as a white powder.

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-3425e444e7294d57a805866baa3b6bb7
Source dataset
uspto-grants-2015_09
Patent number
US09120776B2

Reaction notes

Loading…