反应详情

A solution of the compound obtained in Step 1 (221 mg, 0.70 mmol) in TFA (1 mL, 12.98 mmol) was stirred at room temperature for 15 min, and concentrated under reduced pressure. To the residue were added ethyl acetate and 1N aqueous sodium hydroxide solution, and the organic layer was separated. The organic layer was washed with water and saturated brine, and dried, and the solvent was evaporated under reduced pressure to give 3-amino-N-(4-cyanobenzyl)-2-methylpropanamide (112 mg, 0.515 mmol, 74.0%) as a white powder.

1. concentrationconcentrated under reduced pressure
2. additionTo the residue were added ethyl acetate and 1N aqueous sodium hydroxide solution
3. customthe organic layer was separated
4. washThe organic layer was washed with water and saturated brine
5. customdried
6. customthe solvent was evaporated under reduced pressure