Trifluoroacetic acid → HCID 67973168, compound

HRID 2272633Notes

Reaction equation

HRID 2272633 reaction equation
[CH3:1][O:2][C:3](=[O:29])[C@H:4]([OH:28])[CH2:5][N:6]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:18][CH:17]=1)[NH:7]C(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:29])[C@H:4]([OH:28])[CH2:5][N:6]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:18][CH:17]=1)[NH2:7]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67972627HCID 67972627, compound

Product 1

HCID 67973168HCID 67973168, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(R)-3-(N-biphenyl-4-ylmethyl-N′-t-butoxycarbonylhydrazino)-2-hydroxypropionic acid methyl ester (300 mg, 749 μmol, 1.0 eq.) was dissolved in DCM (3.0 mL). TFA (3.0 mL) was added and the mixture was stirred at room temperature until the reaction was complete (approximately 1 hour). The mixture was concentrated to yield the title compound, which was used without further purification.

Workup

  1. custom(approximately 1 hour)
  2. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-e9b77937677b4065834b762f43399000
Source dataset
uspto-grants-2015_09
Patent number
US09120758B2

Reaction notes

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