反应详情

To a solution of (S)-3-{4-[2-(4-cyano-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-ylmethoxy]-phenyl}-hex-4-ynoic acid ethyl ester (0.130 g, 0.2795 mmol) in THF (10 mL) is added potassium trimethylsilanoate (0.143 g, 1.118 mmol) and the reaction mixture is stirred at room temperature for 2 hours. The reaction mixture is evaporated to dryness, the residue is washed with n-pentane, redissolved in water (5 mL) and is acidified with saturated citric acid solution (pH ˜5). The precipitated solid is filtered, washed with water, and dried to give the title compound as an off-white solid (0.113 g, 56.5%). LCMS m/z 437 (M+H)+.

1. customThe reaction mixture is evaporated to dryness
2. washthe residue is washed with n-pentane
3. dissolutionredissolved in water (5 mL)
4. filtrationThe precipitated solid is filtered
5. washwashed with water
6. customdried