3-(3,4-dichlorophenyl)-N-methoxy-N-methylpropanamide → 4-(3,4-Dichlorophenyl)butan-2-one

HRID 2272855Notes

Reaction equation

HRID 2272855 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][C:11](N(OC)C)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8].[CH3:17][Mg]Br>CCOCC>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][C:11](=[O:12])[CH3:17])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 867281793-(3,4-dichlorophenyl)-N-methoxy-N-methylpropanamideHCID 178418573HCID 178418573, compound

Product 1

HCID 242613834-(3,4-Dichlorophenyl)butan-2-one

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
0 °C

Procedure

At 0° C. to a solution of 3-(3,4-dichlorophenyl)-N-methoxy-N-methylpropanamide (569 mg, 2.17 mmol) in ether (10 mL) was added drop wise methyl magnesium bromide (2.17 mL, 6.51 mmol) and the solution was stirred at 0° C. for 1 h. The reaction mixture was allowed to warm up to rt and stirred for 18 h.

Workup

  1. temperatureto warm up to rt
  2. stirringstirred for 18 h.

Sources & evidence

ORD record
ord-d22288dc80f54ce58190125990416f3b
Source dataset
uspto-grants-2015_09
Patent number
US09120794B2

Reaction notes

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