Trimethylsilyl triflate → HCID 86660683, compound

HRID 2272885Notes

Reaction equation

HRID 2272885 reaction equation
[CH3:1]N(C)C1(C2C=CC=CC=2)CCC(=O)CC1.[CH3:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][CH:22]=[C:21]2[CH2:27][CH2:28][OH:29].C[Si](OS(C(F)(F)F)(=O)=O)(C)C>[OH-].[Na+]>[CH3:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][C:22]1[CH2:1][O:29][CH2:28][CH2:27][C:21]2=1

Participants

5

Reactant 3

HCID 65367Trimethylsilyl triflateHCID 114244924-(Dimethylamino)-4-phenylcyclohexan-1-oneHCID 12272816HCID 12272816, compound

Product 1

HCID 86660683HCID 86660683, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

4-Dimethylamino-4-phenylcyclohexanone (325 mg, 1.5 mmoles) and 2-(5-methyl-1H-indol-3-yl)-ethanol (“5-methyltryptophol”, 262 mg, 1.5 mmoles) were initially introduced into abs. MC (10 ml) under argon. Trifluoromethanesulfonic acid trimethylsilyl ester (0.3 ml, 1.55 mmoles) was then added very rapidly. The mixture was stirred at room temperature for 24 hours. For working up, 1 M NaOH (20 ml) was added to the reaction mixture and the mixture was stirred for 30 min. The organic phase was separated, and the aqueous phase which remained was extracted with MC (3×20 ml). The combined organic phases were washed with water (2×30 ml) and dried over sodium sulfate. Methanol (30 ml) was added to the solid residue obtained after the solvent had been distilled off, and the mixture was heated, and stirred for 15 hours. The suspended solid was filtered out with suction. One of the two possible diastereoisomers of 1,143-dimethylamino-3-phenylpentamethylene)-6-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole was obtained (430 mg, m.p. 259-270° C.). 350 mg of this were dissolved in hot ethanol (300 ml), and a similarly hot solution of citric acid (300 mg, 1.56 mmoles) in ethanol (10 ml) was added. After approx. 15 minutes, crystals precipitated out at the boiling point. After cooling to approx. 5° C., the mixture was left to stand for 2 hours. The resulting solid was filtered out with suction. It was possible to obtain the hemicitrate of 1,1-(3-dimethylamino-3-phenylpentamethylene)-6-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole in this way in a yield of 380 mg (white solid, m.p. 243-265° C.).

Workup

  1. stirringthe mixture was stirred for 30 min
  2. customThe organic phase was separated
  3. extractionthe aqueous phase which remained was extracted with MC (3×20 ml)
  4. washThe combined organic phases were washed with water (2×30 ml)
  5. dry with materialdried over sodium sulfate
  6. additionMethanol (30 ml) was added to the solid residue
  7. customobtained after the solvent
  8. distillationhad been distilled off
  9. temperaturethe mixture was heated
  10. stirringstirred for 15 hours
  11. filtrationThe suspended solid was filtered out with suction

Sources & evidence

ORD record
ord-c44aea0ff6ac490da33615505c1eef17
Source dataset
uspto-grants-2015_09
Patent number
US09120797B2

Reaction notes

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