Hydrochloric Acid → HCID 117974068, compound

Participants

Reaction Steps

0.37 g of potassium hydroxide dissolved in 1 ml of an aqueous solution was added to a mixture of 0.71 g of 5-ethylthiothiazole-4-carboxylic acid ethyl ester and 5 ml of methanol, under ice cooling, then the mixture was stirred at room temperature for 2 hours. 1 N hydrochloric acid was poured into the reaction mixture under ice cooling, and the precipitated solid was filtered. The resulting solid was washed with 0.1 N hydrochloric acid and n-hexane, then dried to obtain 0.59 g of 5-ethylthiothiazole-4-carboxylic acid hydrochloride.

Provenance & Evidence