Hydrochloric Acid → HCID 117974068, compound

HRID 2272921Notes

Reaction equation

HRID 2272921 reaction equation
[OH-].[K+].C([O:5][C:6]([C:8]1[N:9]=[CH:10][S:11][C:12]=1[S:13][CH2:14][CH3:15])=[O:7])C.[ClH:16]>CO>[ClH:16].[CH2:14]([S:13][C:12]1[S:11][CH:10]=[N:9][C:8]=1[C:6]([OH:7])=[O:5])[CH3:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 117779798HCID 117779798, compound

Product 1

HCID 117974068HCID 117974068, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.37 g of potassium hydroxide dissolved in 1 ml of an aqueous solution was added to a mixture of 0.71 g of 5-ethylthiothiazole-4-carboxylic acid ethyl ester and 5 ml of methanol, under ice cooling, then the mixture was stirred at room temperature for 2 hours. 1 N hydrochloric acid was poured into the reaction mixture under ice cooling, and the precipitated solid was filtered. The resulting solid was washed with 0.1 N hydrochloric acid and n-hexane, then dried to obtain 0.59 g of 5-ethylthiothiazole-4-carboxylic acid hydrochloride.

Workup

  1. filtrationthe precipitated solid was filtered
  2. washThe resulting solid was washed with 0.1 N hydrochloric acid and n-hexane
  3. customdried

Sources & evidence

ORD record
ord-a2a1cdc0d7a74f609d7b063e89ef3891
Source dataset
uspto-grants-2015_09
Patent number
US09120792B2

Reaction notes

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