Acetonitrile → HCID 117974232, compound

HRID 2272922Notes

Reaction equation

HRID 2272922 reaction equation
[CH3:1][NH:2][C:3]1[C:8]([NH2:9])=[CH:7][C:6]([C:10]([F:13])([F:12])[F:11])=[CH:5][N:4]=1.C1N=CN([C:19](N2C=NC=C2)=[O:20])C=1.C(#N)C>O>[CH3:1][N:2]1[C:3]2=[N:4][CH:5]=[C:6]([C:10]([F:13])([F:11])[F:12])[CH:7]=[C:8]2[NH:9][C:19]1=[O:20]

Participants

5

Reactant 3

HCID 6342AcetonitrileHCID 682631,1'-CarbonyldiimidazoleHCID 2735930N2-Methyl-5-(trifluoromethyl)pyridine-2,3-diamine

Product 1

HCID 117974232HCID 117974232, compoundYield 92.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 1.91 g of N2-methyl-5-trifluoromethylpyridine-2,3-diamine, 3.24 g of carbodiimidazole and 10 ml of acetonitrile was stirred at 50° C. for 1 hour and at 80° C. for 2 hours. Water was poured into the cooled reaction mixture, and the precipitated crystal was obtained by filtration and dried to obtain 2.0 g of 3-methyl-6-trifluoromethyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one.

Workup

  1. customthe precipitated crystal was obtained by filtration
  2. customdried

Sources & evidence

ORD record
ord-4ea84d746c984934bd4efb551631caed
Source dataset
uspto-grants-2015_09
Patent number
US09120792B2

Reaction notes

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