HCID 71765124, compound → HCID 71765123, compound

HRID 2272981Notes

Reaction equation

HRID 2272981 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[O:10])[NH:8][C:7]([C:11]3[CH:16]=[CH:15][C:14]([C:17](=[CH2:22])[CH2:18][CH2:19][CH2:20][OH:21])=[CH:13][CH:12]=3)=[CH:6][N:5]2[CH:23]=1.FC1C=C2C(=O)NC(C3C=CC(/C(/C)=C/CCO)=CC=3)=CN2C=1>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[O:10])[NH:8][C:7]([C:11]3[CH:12]=[CH:13][C:14]([C:17]4([CH3:22])[CH2:18][CH2:19][CH2:20][O:21]4)=[CH:15][CH:16]=3)=[CH:6][N:5]2[CH:23]=1

Participants

3

Reactant 2

HCID 71765124HCID 71765124, compoundHCID 89826303HCID 89826303, compound

Product 1

HCID 71765123HCID 71765123, compound

Procedure

7-fluoro-3-[4-(4-hydroxy-1-methylene-butyl)-phenyl]-2H-pyrrolo[1,2-a]pyrazin-1-one (contains some of the isomer 7-fluoro-3-[4-((E)-4-hydroxy-1-methyl-but-1-enyl)-phenyl]-2H-pyrrolo[1,2-a]pyrazin-1-one); HPLC/MS 2.32 (B), [M+H] 313; 1H NMR (400 MHz, DMSO-d6) δ ppm 10.98 (s, 1H), 7.69-7.53 (m, 3H), 7.53-7.43 (m, 3H), 6.75 (m, 1H), 6.45-6.39 (m, 2H), 4.41 (t, J=5.2 Hz, 1H), 3.45 (td, J=6.4, 5.0 Hz, 2H), 2.29-2.19 (m, 2H), 1.66-1.54 (m, 2H).

Sources & evidence

ORD record
ord-2dd72a22a0724bfdb1f7211938aca3da
Source dataset
uspto-grants-2015_09
Patent number
US09120805B2

Reaction notes

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