HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-3,5-dimethoxybenzene → 4-[2-(3,5-Dimethoxy-phenylamino)-[1,2,4]triazolo[1,5-a]pyrazin-8-yl]-piperazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-3,5-dimethoxybenzene | HCID 81502 | — |
| Reactant | Piperazin-2-one | HCID 231360 | — |
| Reactant | 8-Chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-amine | HCID 77231010 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-[2-(3,5-Dimethoxy-phenylamino)-[1,2,4]triazolo[1,5-a]pyrazin-8-yl]-piperazin-2-one | HCID 71721770 | — |
Reaction Conditions
| Temperature | 180 °C |
|---|
Reaction Steps
Piperazin-2-one (1.1 eq), 8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine (1 eq) are dissolved in DMF and heated to 180° C. in a microwave for 1 h following general procedure 3. The intermediate is reacted with 1-chloro-3,5-dimethoxy-benzene under amination conditions as described in general procedure 3 giving the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120804B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-c752705dd04d427f8705a72f5dd870ca |
| Source note | uspto-grants-2015_09 |