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HRID2272999

反应详情

EQUATION

反应方程式

HRID 2272999 的结构方程式

REACTANTS

反应物

3
结构：COc1cc(Cl)cc(OC)c1
HCID81502

Benzene, 1-chloro-3,5-dimethoxy-

C8H9ClO2

结构：O=C1CNCCN1
HCID231360

Piperazin-2-one

C4H8N2O

结构：Nc1nc2c(Cl)nccn2n1
HCID77231010

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc(Nc2nc3c(N4CCNC(=O)C4)nccn3n2)cc(OC)c1
HCID71721770

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度
180 °C

PROCEDURE

实验过程

Piperazin-2-one (1.1 eq), 8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine (1 eq) are dissolved in DMF and heated to 180° C. in a microwave for 1 h following general procedure 3. The intermediate is reacted with 1-chloro-3,5-dimethoxy-benzene under amination conditions as described in general procedure 3 giving the title compound as a solid.