6-Chloro-1,3-dihydroindol-2-one → 6-[8-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-1,3-dihydro-indol-2-one

HRID 2273005Notes

Reaction equation

HRID 2273005 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[C:8]3[N:9]([N:13]=[C:14]([NH2:16])[N:15]=3)[CH:10]=[CH:11][N:12]=2)[CH:4]=[N:3]1.Cl[C:18]1[CH:26]=[C:25]2[C:21]([CH2:22][C:23](=[O:27])[NH:24]2)=[CH:20][CH:19]=1>>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[C:8]3[N:9]([N:13]=[C:14]([NH:16][C:18]4[CH:26]=[C:25]5[C:21]([CH2:22][C:23](=[O:27])[NH:24]5)=[CH:20][CH:19]=4)[N:15]=3)[CH:10]=[CH:11][N:12]=2)[CH:4]=[N:3]1

Participants

3

Reactant 2

HCID 7363446-Chloro-1,3-dihydroindol-2-oneHCID 665833238-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine

Product 1

HCID 897759366-[8-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-1,3-dihydro-indol-2-one

Procedure

8-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-amine, synthesized as described earlier, is coupled with 6-chloro-oxindol according to general procedure 2.

Sources & evidence

ORD record
ord-95e9e90ed3784d53a5f9adb7bce6f6b3
Source dataset
uspto-grants-2015_09
Patent number
US09120804B2

Reaction notes

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