2-(4-Bromophenyl)propan-2-ol → 2-{4-[8-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-phenyl}-propan-2-ol

HRID 2273006Notes

Reaction equation

HRID 2273006 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:11])([CH3:10])[CH3:9])=[CH:4][CH:3]=1.[CH3:12][N:13]1[CH:17]=[C:16]([C:18]2[C:19]3[N:20]([N:24]=[C:25]([NH2:27])[N:26]=3)[CH:21]=[CH:22][N:23]=2)[CH:15]=[N:14]1>>[CH3:12][N:13]1[CH:17]=[C:16]([C:18]2[C:19]3[N:20]([N:24]=[C:25]([NH:27][C:2]4[CH:7]=[CH:6][C:5]([C:8]([OH:11])([CH3:10])[CH3:9])=[CH:4][CH:3]=4)[N:26]=3)[CH:21]=[CH:22][N:23]=2)[CH:15]=[N:14]1

Participants

3

Reactant 2

HCID 126819202-(4-Bromophenyl)propan-2-olHCID 665833238-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine

Product 1

HCID 717218012-{4-[8-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-phenyl}-propan-2-ol

Procedure

2-(4-Bromophenyl)propan-2-ol and 8-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-amine are reacted under Buchwald Hartwig conditions as described in general procedure 2.

Sources & evidence

ORD record
ord-f8666d841ebd40c8b1bdfb80f3284ca0
Source dataset
uspto-grants-2015_09
Patent number
US09120804B2

Reaction notes

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