1-(p-Chlorophenyl)cyclopropanecarbonitrile → 1-{4-[8-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-phenyl}-cyclopropanecarbonitrile

HRID 2273008Notes

Reaction equation

HRID 2273008 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[C:8]3[N:9]([N:13]=[C:14]([NH2:16])[N:15]=3)[CH:10]=[CH:11][N:12]=2)[CH:4]=[N:3]1.Cl[C:18]1[CH:23]=[CH:22][C:21]([C:24]2([C:27]#[N:28])[CH2:26][CH2:25]2)=[CH:20][CH:19]=1>>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[C:8]3[N:9]([N:13]=[C:14]([NH:16][C:18]4[CH:23]=[CH:22][C:21]([C:24]5([C:27]#[N:28])[CH2:25][CH2:26]5)=[CH:20][CH:19]=4)[N:15]=3)[CH:10]=[CH:11][N:12]=2)[CH:4]=[N:3]1

Participants

3

Reactant 2

HCID 986661-(p-Chlorophenyl)cyclopropanecarbonitrileHCID 665833238-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine

Product 1

HCID 897671171-{4-[8-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-phenyl}-cyclopropanecarbonitrile

Procedure

Reaction of 8-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-amine with 1-(4-chlorophenyl)-1-cyclopropanecarbonitrile following general procedure 2 gives the title compound as a solid.

Sources & evidence

ORD record
ord-f48b86b7aa694e3eb000eec0fe058af7
Source dataset
uspto-grants-2015_09
Patent number
US09120804B2

Reaction notes

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