Lithium Hydroxide → HCID 86731623, compound

HRID 2273106Notes

Reaction equation

HRID 2273106 reaction equation
[CH3:1][C@:2]1([C:18]([O:20]C)=[O:19])[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=1.[Li+:22].[OH-]>>[CH3:1][C@:2]1([C:18]([O-:20])=[O:19])[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:15])([F:17])[F:16])[CH:9]=1.[Li+:22]

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 71204758HCID 71204758, compound

Product 1

HCID 86731623HCID 86731623, compound

Procedure

The title compound (D17) (37 mg) was prepared according to the general procedure for esters hydrolysis starting from (R)-methyl 2-methyl-1-(3-(trifluoromethyl)benzyl)pyrrolidine-2-carboxylate (D10) (47 mg). (LiOH: 2 eq; reaction time: 18 hrs).

Sources & evidence

ORD record
ord-2cd5d1864ba347108deab68e38914526
Source dataset
uspto-grants-2015_09
Patent number
US09120824B2

Reaction notes

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