Lithium hydroxide, monohydrate → HCID 86731626, compound

HRID 2273124Notes

Reaction equation

HRID 2273124 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][CH:29]=1)[CH2:5][N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH:7]1[C:12]([NH:14][C@H:15]([C:17]1[CH:26]=[CH:25][C:20]([C:21]([O:23]C)=[O:22])=[CH:19][CH:18]=1)[CH3:16])=[O:13].O[Li:31].O>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][CH:29]=1)[CH2:5][N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH:7]1[C:12]([NH:14][C@H:15]([C:17]1[CH:18]=[CH:19][C:20]([C:21]([O-:23])=[O:22])=[CH:25][CH:26]=1)[CH3:16])=[O:13].[Li+:31]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71186327HCID 71186327, compound

Product 1

HCID 86731626HCID 86731626, compound

Procedure

The title compound E2 (60 mg) was prepared according to the general procedure for esters hydrolysis starting from methyl 4-((1S)-1-(1-(3-methylbenzyl)piperidine-2-carboxamido)ethyl)benzoate (D19) (42 mg). (LiOH H2O: 1.75 eq; reaction time: 3 hrs)

Sources & evidence

ORD record
ord-a60b9cd172554209b527a5fef9797f18
Source dataset
uspto-grants-2015_09
Patent number
US09120824B2

Reaction notes

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