Lithium hydroxide, monohydrate → HCID 86731628, compound

HRID 2273126Notes

Reaction equation

HRID 2273126 reaction equation
[F:1][C:2]([F:32])([F:31])[C:3]1[CH:4]=[C:5]([CH:28]=[CH:29][CH:30]=1)[CH2:6][N:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH:8]1[C:13]([NH:15][C@H:16]([C:18]1[CH:27]=[CH:26][C:21]([C:22]([O:24]C)=[O:23])=[CH:20][CH:19]=1)[CH3:17])=[O:14].O[Li:34].O>>[F:31][C:2]([F:1])([F:32])[C:3]1[CH:4]=[C:5]([CH:28]=[CH:29][CH:30]=1)[CH2:6][N:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH:8]1[C:13]([NH:15][C@H:16]([C:18]1[CH:19]=[CH:20][C:21]([C:22]([O-:24])=[O:23])=[CH:26][CH:27]=1)[CH3:17])=[O:14].[Li+:34]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71186472HCID 71186472, compound

Product 1

HCID 86731628HCID 86731628, compound

Procedure

The title compound (E4) (20 mg) was prepared according to the general procedure for esters hydrolysis starting from methyl 4-((1S)-1-(1-(3-(trifluoromethyl)benzyl)piperidine-2-carboxamido)ethyl)benzoate (D21) (45 mg). (LiOH H2O: 1.75 eq; reaction time: 3 hrs)

Sources & evidence

ORD record
ord-d66ae90d94ff49e0b0e49f7419826334
Source dataset
uspto-grants-2015_09
Patent number
US09120824B2

Reaction notes

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