Lithium hydroxide, monohydrate → HCID 71486727, compound

HRID 2273127Notes

Reaction equation

HRID 2273127 reaction equation
[F:1][C:2]([F:32])([F:31])[C:3]1[CH:4]=[C:5]([CH:28]=[CH:29][CH:30]=1)[CH2:6][N:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[C:13]([NH:15][C@H:16]([C:18]1[CH:27]=[CH:26][C:21]([C:22]([O:24]C)=[O:23])=[CH:20][CH:19]=1)[CH3:17])=[O:14].O[Li:34].O>>[F:31][C:2]([F:1])([F:32])[C:3]1[CH:4]=[C:5]([CH:28]=[CH:29][CH:30]=1)[CH2:6][N:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[C:13]([NH:15][C@H:16]([C:18]1[CH:19]=[CH:20][C:21]([C:22]([O-:24])=[O:23])=[CH:26][CH:27]=1)[CH3:17])=[O:14].[Li+:34]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71204757HCID 71204757, compound

Product 1

HCID 71486727HCID 71486727, compound

Procedure

The title compound (E5) (5.02 mg) was prepared according to the general procedure for esters hydrolysis starting from methyl 4-((S)-1-((R)-1-(3-(trifluoromethyl)benzyl)piperidine-2-carboxamido)ethyl)benzoate (D22) (19 mg). (LiOH H2O: 1.75 eq; reaction time: 3 hrs)

Sources & evidence

ORD record
ord-7148a22ce12e4c4b85f1e0033beeaa1b
Source dataset
uspto-grants-2015_09
Patent number
US09120824B2

Reaction notes

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