Lithium hydroxide, monohydrate → HCID 86731634, compound

HRID 2273130Notes

Reaction equation

HRID 2273130 reaction equation
[F:1][C:2]([F:33])([F:32])[O:3][C:4]1[CH:5]=[C:6]([CH:29]=[CH:30][CH:31]=1)[CH2:7][N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@@H:9]1[C:14]([NH:16][C@H:17]([C:19]1[CH:28]=[CH:27][C:22]([C:23]([O:25]C)=[O:24])=[CH:21][CH:20]=1)[CH3:18])=[O:15].O[Li:35].O>>[F:32][C:2]([F:1])([F:33])[O:3][C:4]1[CH:5]=[C:6]([CH:29]=[CH:30][CH:31]=1)[CH2:7][N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@@H:9]1[C:14]([NH:16][C@H:17]([C:19]1[CH:28]=[CH:27][C:22]([C:23]([O-:25])=[O:24])=[CH:21][CH:20]=1)[CH3:18])=[O:15].[Li+:35]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71204759HCID 71204759, compound

Product 1

HCID 86731634HCID 86731634, compound

Procedure

The title compound (E8) (51 mg) was prepared according to the general procedure for esters hydrolysis starting from methyl 4-((S)-1-((R)-1-(3-(trifluoromethoxy)benzyl)piperidine-2-carboxamido)ethyl)benzoate (D25) (52 mg). (LiOH H2O: 3 eq; reaction time: 3 hrs)

Sources & evidence

ORD record
ord-058385bc9feb419aaf0ffcafe738fa64
Source dataset
uspto-grants-2015_09
Patent number
US09120824B2

Reaction notes

Loading…