Lithium hydroxide, monohydrate → lithium (R)-4-(1-(1-(3-fluorobenzyl)piperidine-2-carboxamido)cyclopropyl)benzoate

HRID 2273133Notes

Reaction equation

HRID 2273133 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][CH:30]=1)[CH2:5][N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][C@@H:7]1[C:12]([NH:14][C:15]1([C:18]2[CH:27]=[CH:26][C:21]([C:22]([O:24]C)=[O:23])=[CH:20][CH:19]=2)[CH2:17][CH2:16]1)=[O:13].O[Li:32].O>>[F:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][CH:30]=1)[CH2:5][N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][C@@H:7]1[C:12]([NH:14][C:15]1([C:18]2[CH:19]=[CH:20][C:21]([C:22]([O-:24])=[O:23])=[CH:26][CH:27]=2)[CH2:16][CH2:17]1)=[O:13].[Li+:32]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71204706(R)-methyl 4-(1-(1-(3-fluorobenzyl)piperidine-2-carboxamido)cyclopropyl)benzoate

Product 1

HCID 86731638lithium (R)-4-(1-(1-(3-fluorobenzyl)piperidine-2-carboxamido)cyclopropyl)benzoate

Procedure

The title compound (E11) (61 mg) was prepared according to the general procedure for esters hydrolysis starting from (R)-methyl 4-(1-(1-(3-fluorobenzyl)piperidine-2-carboxamido)cyclopropyl)benzoate (D28) (62 mg). (LiOH H2O: 3 eq; reaction time: 3 hrs)

Sources & evidence

ORD record
ord-d3ce8f300159458e9e0e8f1c6863abb2
Source dataset
uspto-grants-2015_09
Patent number
US09120824B2

Reaction notes

Loading…