Lithium hydroxide, monohydrate → HCID 71486667, compound

HRID 2273135Notes

Reaction equation

HRID 2273135 reaction equation
[F:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]2[C:13]([NH:15][C:16]2([C:19]3[CH:28]=[CH:27][C:22]([C:23]([O:25]C)=[O:24])=[CH:21][CH:20]=3)[CH2:18][CH2:17]2)=[O:14])=[CH:4][C:3]=1[C:31]([F:34])([F:33])[F:32].O[Li:36].O>>[F:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]2[C:13]([NH:15][C:16]2([C:19]3[CH:28]=[CH:27][C:22]([C:23]([O-:25])=[O:24])=[CH:21][CH:20]=3)[CH2:18][CH2:17]2)=[O:14])=[CH:4][C:3]=1[C:31]([F:34])([F:32])[F:33].[Li+:36]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71204754HCID 71204754, compound

Product 1

HCID 71486667HCID 71486667, compound

Procedure

The title compound (E13) (11.1 mg) was prepared according to the general procedure for esters hydrolysis starting from (R)-methyl 4-(1-(1-(4-fluoro-3-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate (D30) (35 mg). (LiOH H2O: 3 eq; reaction time: 3 hrs)

Sources & evidence

ORD record
ord-3d5ec384a11e4712b2b551b60442baaf
Source dataset
uspto-grants-2015_09
Patent number
US09120824B2

Reaction notes

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