Lithium hydroxide, monohydrate → HCID 86731640, compound

HRID 2273136Notes

Reaction equation

HRID 2273136 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][CH:28]=1)[CH2:5][N:6]1[CH2:10][CH2:9][CH2:8][C@@H:7]1[C:11]([NH:13][C@H:14]([C:16]1[CH:25]=[CH:24][C:19]([C:20]([O:22]C)=[O:21])=[CH:18][CH:17]=1)[CH3:15])=[O:12].O[Li:30].O>>[F:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][CH:28]=1)[CH2:5][N:6]1[CH2:10][CH2:9][CH2:8][C@@H:7]1[C:11]([NH:13][C@H:14]([C:16]1[CH:17]=[CH:18][C:19]([C:20]([O-:22])=[O:21])=[CH:24][CH:25]=1)[CH3:15])=[O:12].[Li+:30]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71204715HCID 71204715, compound

Product 1

HCID 86731640HCID 86731640, compound

Procedure

The title compound (E14) (48 mg) was prepared according to the general procedure for esters hydrolysis starting from methyl 4-((S)-1-((R)-1-(3-fluorobenzyl)pyrrolidine-2-carboxamido)ethyl)benzoate (D31) (53 mg). (LiOH H2O: 1.5 eq; reaction time: 24 hrs)

Sources & evidence

ORD record
ord-aa7bb58348924bd7b49c38e21940bc1a
Source dataset
uspto-grants-2015_09
Patent number
US09120824B2

Reaction notes

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