Lithium hydroxide, monohydrate → HCID 71186627, compound

HRID 2273139Notes

Reaction equation

HRID 2273139 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[F:29])[CH2:5][N:6]1[CH2:10][CH2:9][CH2:8][C@@H:7]1[C:11]([NH:13][C@H:14]([C:16]1[CH:25]=[CH:24][C:19]([C:20]([O:22]C)=[O:21])=[CH:18][CH:17]=1)[CH3:15])=[O:12].O[Li:31].O>>[F:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[F:29])[CH2:5][N:6]1[CH2:10][CH2:9][CH2:8][C@@H:7]1[C:11]([NH:13][C@H:14]([C:16]1[CH:25]=[CH:24][C:19]([C:20]([O-:22])=[O:21])=[CH:18][CH:17]=1)[CH3:15])=[O:12].[Li+:31]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71186519HCID 71186519, compound

Product 1

HCID 71186627HCID 71186627, compound

Procedure

The title compound (E17) (36 mg) was prepared according to the general procedure for esters hydrolysis starting from methyl 4-((S)-1-((R)-1-(3,4-difluorobenzyl)pyrrolidine-2-carboxamido)ethyl)benzoate (D34) (38 mg). (LiOH H2O: 1.5 eq; reaction time: 24 hrs)

Sources & evidence

ORD record
ord-412d80282c5e433eac2b0be6ba0dd084
Source dataset
uspto-grants-2015_09
Patent number
US09120824B2

Reaction notes

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