Lithium hydroxide, monohydrate → HCID 71475848, compound

HRID 2273140Notes

Reaction equation

HRID 2273140 reaction equation
[OH:1][C@H:2]1[CH2:6][N:5]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[C@@H:4]([C:18]([NH:20][C@H:21]([C:23]2[CH:32]=[CH:31][C:26]([C:27]([O:29]C)=[O:28])=[CH:25][CH:24]=2)[CH3:22])=[O:19])[CH2:3]1.O[Li:34].O>>[OH:1][C@H:2]1[CH2:6][N:5]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:15])[F:16])[CH:9]=2)[C@@H:4]([C:18]([NH:20][C@H:21]([C:23]2[CH:24]=[CH:25][C:26]([C:27]([O-:29])=[O:28])=[CH:31][CH:32]=2)[CH3:22])=[O:19])[CH2:3]1.[Li+:34]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71186561HCID 71186561, compound

Product 1

HCID 71475848HCID 71475848, compound

Procedure

The title compound (E19) (9 mg) was prepared according to the general procedure for esters hydrolysis starting from methyl 4-((S)-1-((2R,4R)-4-hydroxy-1-(3-(trifluoromethyl)benzyl)pyrrolidine-2-carboxamido)ethyl)benzoate (D36) (10.3 mg). (LiOH H2O: 2 eq; reaction time: 18 hrs)

Sources & evidence

ORD record
ord-f43ca311611240b1a94f325de13253e4
Source dataset
uspto-grants-2015_09
Patent number
US09120824B2

Reaction notes

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