Aluminium lithium hydride → 4-Hydroxymethyl-6-methoxy-quinoline-3-ol

HRID 2273177Notes

Reaction equation

C[O:2][C:3]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH3:16])[CH:13]=2)[N:8]=[CH:7][C:6]=1[OH:17])=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[OH:2][CH2:3][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH3:16])[CH:13]=2)[N:8]=[CH:7][C:6]=1[OH:17]

Participants

Conditions

Temperature: 0 °C

Procedure

A solution of 3-hydroxy-6-methoxyquinoline-4-carboxylic acid methyl ester (5 g, 21.44 mmol, 1.0 eq) in tetrahydrofuran (40 mL) is added at 0° C. to a stirred solution of lithium aluminium hydride (1.63 g, 42.88 mmol, 2.0 eq) in tetrahydrofuran (200 mL). After 1 hour stirring at 0° C., the reaction mixture is cautiously quenched with ice-water (5 mL). After 30 minutes stirring at room temperature, the pH is adjusted to 6 by the addition of a 1N hydrochloric acid aqueous solution, the resulting mixture is filtered and the filtrate is concentrated to afford 4-hydroxymethyl-6-methoxy-quinoline-3-ol as a yellow solid (4 g, 90% yield).

Workup

customthe reaction mixture is cautiously quenched with ice-water (5 mL)
stirringAfter 30 minutes stirring at room temperature
additionthe pH is adjusted to 6 by the addition of a 1N hydrochloric acid aqueous solution
filtrationthe resulting mixture is filtered
concentrationthe filtrate is concentrated

Sources & evidence

ORD record: ord-35e702a8d237489199475acfce3844f2
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09120822B2

Reaction notes

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