HCID 44443119, compound → HCID 44443120, compound

HRID 2273294Notes

Reaction equation

HRID 2273294 reaction equation
[Cl:1][C:2]1[C:19]([Cl:20])=[CH:18][C:5]2[NH:6][C:7]([C:9]3([C:14]([F:17])([F:16])[F:15])[CH:13]=[CH:12][CH2:11][O:10]3)=[N:8][C:4]=2[CH:3]=1>CO.[Rh]>[Cl:1][C:2]1[C:19]([Cl:20])=[CH:18][C:5]2[NH:6][C:7]([C:9]3([C:14]([F:17])([F:15])[F:16])[CH2:13][CH2:12][CH2:11][O:10]3)=[N:8][C:4]=2[CH:3]=1

Participants

4

Reactant 1

HCID 44443119HCID 44443119, compound

Product 1

HCID 44443120HCID 44443120, compound

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 887MethanolSolvent

Procedure

To 5,6-dichloro-2-(2-trifluoromethyl-2,5-dihydro-furan-2-yl)-1H-benzimidazole (95 mg) in methanol (5 mL) was added Rhodium on alumina (32 mg). The resulting mixture was stirred at room temperature under a H2 atmosphere via balloon for 5 hours. The reaction mixture was then filtered through a pad of Celite®, rinsed with Et2O, and concentrated to yield the title compound as a tan solid.

Workup

  1. filtrationThe reaction mixture was then filtered through a pad of Celite®
  2. washrinsed with Et2O
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-b8800d610f9d4a04ad2e9ee615685118
Source dataset
uspto-grants-2015_09
Patent number
US09120830B2

Reaction notes

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