Diethyl Ether → HCID 57500384, compound

HRID 2273547Notes

Reaction equation

HRID 2273547 reaction equation
C(OCC)C.[NH2:6][C:7]1[CH:16]=[CH:15][C:14]([C:17]([C:19]2[N:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]3=[C:21]([N:28]=C(C3C=CC=CC=3)C3C=CC=CC=3)[N:20]=2)=[O:18])=[CH:13][C:8]=1[C:9]([O:11][CH3:12])=[O:10].[Cl:42]CCl>CO>[ClH:42].[NH2:6][C:7]1[CH:16]=[CH:15][C:14]([C:17]([C:19]2[N:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]3=[C:21]([NH2:28])[N:20]=2)=[O:18])=[CH:13][C:8]=1[C:9]([O:11][CH3:12])=[O:10]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 57500382HCID 57500382, compound

Product 1

HCID 57500384HCID 57500384, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

8 ml of hydrochloric ethyl ether (1 M) are added to the solution of 1.92 g (4.05 mmol) of the imine obtained in stage A above in a mixture of 40 ml of dichloromethane and 8 ml of methanol. The clear orange medium becomes dark red and then a precipitate forms. After 1 hour at ambient temperature, the precipitate is filtered and then washed with dichloromethane and dried under vacuum at 50° C., to give 1.18 g (84%) of the hydrochloride in the form of an ochre powder.

Workup

  1. filtrationthe precipitate is filtered
  2. washwashed with dichloromethane
  3. customdried under vacuum at 50° C.

Sources & evidence

ORD record
ord-2e11b0c6f7ba44b9af27865fe5df6c39
Source dataset
uspto-grants-2015_09
Patent number
US09120819B2

Reaction notes

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