Carbonate Ion → Mepivacaine

HRID 2273578Notes

Reaction equation

HRID 2273578 reaction equation
[CH3:1][C:2]1[C:7]([NH:8][C:9]([CH:11]2[N:16]([CH3:17])[CH2:15][CH2:14][CH2:13][CH2:12]2)=[O:10])=[C:6]([CH3:18])[CH:5]=[CH:4][CH:3]=1.Cl.C(=O)([O-])ON1C(=O)CCC1=O.C(=O)([O-])[O-]>>[CH3:1][C:2]1[C:7]([NH:8][C:9]([CH:11]2[N:16]([CH3:17])[CH2:15][CH2:14][CH2:13][CH2:12]2)=[O:10])=[C:6]([CH3:18])[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 19660Carbonate IonHCID 66070Mepivacaine HydrochlorideHCID 22239412(2,5-Dioxopyrrolidin-1-yl) carbonate

Product 1

HCID 4062Mepivacaine

Procedure

In a first vial, Mepivacaine-HCl (7.2 mg), 4-arm PEG succinimidyl carbonate (60 mg) and 4-arm PEG-SH (60 mg) were dissolved in 250 μL of pH 2.2 buffer. This solution was combined with an equal volume of carbonate buffer (pH 9.7) through a spray kit. Mepivacaine precipitated within the gel upon mixing. The Mepivacaine-loaded TC gel swelled 2-2.5 times its original volume.

Workup

  1. customMepivacaine precipitated within the gel
  2. additionupon mixing

Sources & evidence

ORD record
ord-b88ef554aa43474887397b86fcbf3c25
Source dataset
uspto-grants-2015_09
Patent number
US09125814B2

Reaction notes

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