HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbonate Ion → Mepivacaine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbonate Ion | HCID 19660 | — |
| Reactant | Mepivacaine Hydrochloride | HCID 66070 | — |
| Reactant | (2,5-Dioxopyrrolidin-1-yl) carbonate | HCID 22239412 | — |
| Product | Mepivacaine | HCID 4062 | — |
Reaction Steps
In a first vial, Mepivacaine-HCl (7.2 mg), 4-arm PEG succinimidyl carbonate (60 mg) and 4-arm PEG-SH (60 mg) were dissolved in 250 μL of pH 2.2 buffer. This solution was combined with an equal volume of carbonate buffer (pH 9.7) through a spray kit. Mepivacaine precipitated within the gel upon mixing. The Mepivacaine-loaded TC gel swelled 2-2.5 times its original volume.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09125814B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-b88ef554aa43474887397b86fcbf3c25 |
| Source note | uspto-grants-2015_09 |