N-[2-[N-ethyl-N-[2-[(6-fluoropyridin-2-yl)amino]ethyl]amino]ethyl]-6-iodoquinoxaline-2-carboxamide → n-[2-[n-Ethyl-n-[2-[(6-fluoropyridin-2-yl)amino]ethyl]amino]ethyl]-6-iodoquinoxaline-2-carboxamide dihydrochloride salt

Participants

Reaction Steps

This compound was prepared, starting from compound 16 (251 mg, 0.49 mmol), according to the procedure developed for compound 11 to give compound 17 (231 mg, 0.40 mmol) as a very hygroscopic yellow solid. Yield 80%; mp 99-101° C. (dec.); IR (KBr) ν 1163, 1225, 1421, 1474, 1522, 1622, 1670, 2500-2800, 2850-3000, 3100-3600 cm−1; 1H NMR (400 MHz, DMSO-d6) δ 1.28 (t, 3H, J=7.0 Hz), 3.33 (q, 2H, J=6.6 Hz), 3.62 (m, 2H), 3.80 (m, 6H), 6.12 (dd, 1H, J=2.0, 8.0 Hz), 6.40 (dd, 1H, J=2.0, 8.0 Hz), 7.30 (se, 1H), 7.50 (q, 1H, 4JH-F=8.0 Hz, J=8.0 Hz), 7.92 (d, 1H, J=8.8 Hz), 8.25 (dd, 1H, J=1.8, 8.8 Hz), 8.64 (d, 1H, J=1.6 Hz), 9.38 (t, 1H, J=6.0 Hz), 9.44 (s, 1H), 10.28 (se, 1H); ESI-MS m/z 509.1 [M+H]+; Anal. Calcd for C20H22OIN6F, 2HCl: C, 41.33; H, 4.16; N, 14.46. Found: C, 43.19; H, 4.31; N, 14.74.

Provenance & Evidence